Hyde Park Labs is the South Side of Chicago’s first commercial, purpose-built advanced R&D lab building. The $225 million expansion to Harper Court stands 13 stories and spanning more than 300,000 square feet, the building features nine full floors of Class-A lab and office space, ground-level retail, and four levels of parking. The facility features 40,000 sq. ft. of tenant amenities, including a fifth-floor terrace dubbed “The Lawn,” which has cooking grills, fire pits, and direct access to the interior tenant lounge. Hyde Park Labs also offers private terraces on every floor, secure on-site bike storage, an indoor bar and lounge, and an executive boardroom.

Trammell Crow Company (TCC) and Beacon Capital Partners (Beacon), a real estate developer, owner, and manager of office and life science properties, partnered to deliver Hyde Park Labs located at 5207 South Harper Ave. The partnership is also celebrating the opening of the STEM engagement center for local youth, known as Southside STEM Station, situated on the ground floor of Hyde Park Labs.

“Hyde Park Labs will inspire groundbreaking innovation that will contribute to Chicago’s South Side community and burgeoning life sciences ecosystem,” said Fred Seigel, President and Chief Executive Officer, Beacon Capital Partners.

The University of Chicago reportedly pre-leased approximately 55,000 sq. ft. at Hyde Park Labs. In addition to faculty research, the University space includes its new UChicago Science Incubator, a partnership between the Polsky Center for Entrepreneurship and Innovation and Portal Innovations to translate early-stage deep tech concepts into commercial opportunities. Among the incubator’s first tenants are UChicago-affiliated companies: memQ, Exactics, Signl, Cell Therapy, and Neuro Innovations. The University will also be hosting scientists from IBM with the new National Quantum Algorithm Center in the adjacent Harper Court building, home to the Chicago Quantum Exchange.

“Hyde Park Labs is poised to strengthen the innovation ecosystem that connects academic research with the private sector to the benefit of Chicago and beyond,” said UChicago President Paul Alivisatos. “Bringing together University of Chicago scientists and students with startups and established companies, it will serve as a powerful environment for advancing breakthrough ideas and accelerating their path to real-world impact.”

On May 29, 2025 the Southside STEM Station officially opened on the ground floor of Hyde Park Labs. This new learning hub offers free, quality hands-on STEM programs for students, families, and educators on the city’s South Side. It will feature in-school labs, after-school and summer programs, community events, and teacher professional development to foster inclusive STEM education. The station is expected to kick off its series of STEM summer camps, which will focus on health care careers; technology and computer science; and game development.

“Providing STEM education to South Side youth and sparking their interest in math and science is key to nurturing the next generation of innovators in our city,” said John Carlson, Principal at TCC Midwest.

Development project partners for Hyde Park Labs also includes Elkus Manfredi Architects, Interactive Design Architects, Power Construction, Ujamaa, and Trinal. CBRE is the exclusive marketing and leasing agent.